![]() However, unlike Ryley, Danby developed visible signs of infection within three hours. The same happens to Medical Officer Danby in Lifepod 12. At this point it will warn him that the infection is reaching a critical stage and his skin breaks out into glowing green cysts. The infection only becomes noticeable when Ryley reaches the Disease Research Facility and is prompted by the PDA to perform a self-scan. Ryley Robinson is infected with Kharaa, though he only becomes aware of it after attempting to disable the Quarantine Enforcement Platform, as the deactivation terminal will tell him that he is infected and therefore cannot disable it, thus forcing Ryley to secure a cure in order to leave the planet. This seems to be ineffective as Kharaa still ravages the planet around one thousand years after it was initially released. They will attempt to kill infected fauna to control the spread of the bacterium. Warpers were created to keep the levels of Kharaa to a minimum. According to Architect data, the bacterium is capable of entering the body through the skin, and causes an increase in aggression in its host. It accomplishes this by shutting down the immune system (already making the infected host susceptible to other diseases) and causing genetic mutation to the host's DNA, which causes alterations to the body structure, eventually leading to a total shutdown of the organism due to its inability to keep functioning properly. The PDA estimates that Kharaa incubates in two weeks and quickly kills its host after it reaches a substantial infection level. ![]() The Quarantine Enforcement Platform shoots down all approaching or departing spacecraft to prevent Kharaa being spread to other planets. This prompted the Architects to initiate their emergency quarantine: activating the Quarantine Enforcement Platform. This decimated the planet's ecosystems, as much of the life on the planet died due to the bacterium's immuno-repressive behavior and genetic corruption. After a Sea Dragon Leviathan damaged the Disease Research Facility in an attempt to retrieve its offspring, the previously contained Kharaa bacterium was released onto the planet. ![]() Their core worlds were quarantined off, and research facilities such as the one on 4546B were created to find a cure. It is possible this is not the true death count as the PDA entry only lists these as "Confirmed Deaths" which could imply further dead beyond what was known. It is stated in Architect data that the Kharaa bacterium has killed over 143 billion individuals over the course of time since its discovery, but the data is likely to be around 1000 years old. Kharaa was brought to 4546B by the Architects in an attempt to find a vaccine, as they had established outposts within The Crater.
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